The prothrombin gene G20210A variant: prevalence in a U.K. anticoagulant clinic population
نویسندگان
چکیده
منابع مشابه
Prothrombin G20210A is a bifunctional gene polymorphism.
The G20210A polymorphism has been shown to alter the efficiency of prothrombin mRNA processing. Here we show that the G20210A mutation also alters prothrombin mRNA stability. Three-fold more prothrombin protein and mRNA were produced in NIH-3T3 cells transfected with the prothrombin cDNAs containing the 20210A variant compared to cells expressing the 20210G variant. mRNA stability assays using ...
متن کاملProthrombin gene mutation (G20210A) in healthy Centenarians.
A recently described genetic variant of the prothrombin gene (G to A transition at nucleotide position 20210) is associated with an increased risk of venous thrombosis (1). The 20210A prothrombin allele may precipitate cerebral ischemia or myocardial infarction in young patients with known prothrombotic abnormalities (2, 3). Similarly, it has been demonstrated that factor V Leiden further incre...
متن کاملG20210A prothrombin gene variant and clinical outcome in patients with a first acute coronary syndrome.
BACKGROUND AND OBJECTIVES The prognostic value of the G20210A prothrombin gene polymorphism in patients with a first acute coronary syndrome has not been previously assessed. We conducted a prospective study to investigate this issue. DESIGN AND METHODS Genotyping at the 20210 prothrombin gene locus was performed in 162 patients with a first episode of myocardial infarction (MI) or unstable a...
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We have investigated the prevalence of the Factor II G20210A and Factor V G1691A single nucleotide polymorphisms (SNPs) in a South Indian-Tamil Nadu population. The SNP genotyping was performed using a polymerase chain reaction (PCR)/restriction fragment length polymorphism analysis and by a recently FDA-approved LightCycler real-time PCR assay. Of 72 samples that were genotyped, 4 (5.5%) patie...
متن کاملDouble-homozygosity for factor V Leiden and the prothrombin gene G20210A variant in a young patient with idiopathic venous thrombosis.
1. Fanelli M, Minucci S, Gelmetti V, Nervi C, Gambacorti-Passerini C, Pelicci PG: Constitutive degradation of PML/RARa through the proteasome pathway mediates retinoic acid resistance. Blood 93:1477, 1999 2. Bonn D: Targeting protein breakdown to treat cancer. Molec Med Today 5:48, 1999 3. Delic J, Masdehors P, Omura S, Cosset JM, Dumont J, Binet JL, Magdelenat H: The proteasome inhibitor lacta...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 1997
ISSN: 0007-1048,1365-2141
DOI: 10.1046/j.1365-2141.1997.2353052.x